Introduction The flavonoid hesperidin is a flavanone glycoside (glucoside) comprised of the flavanone (a class of flavonoids) hesperitin and the disaccharide rutinose. Hesperidin is the predominant flavonoid in lemons and oranges. The peel and membranous parts of these fruits have the highest hesperidin concentrations. Therefore, orange juice containing pulp is richer in the flavonoid than that without pulp. Sweet oranges (Citrus sinensis) and tangelos are the richest dietary sources of hesperidin. Hesperidin is classified as a citrus bioflavonoid. Hesperidin, in combination with a flavone glycoside called diosmin, is used in Europe for the treatment of venous insufficiency and hemorrhoids. Hesperidin, rutin and other flavonoids thought to reduce capillary permeability and to have anti-inflammatory action were collectively known as vitamin P. These substances, however, are not vitamins and are no longer referred to, except in older literature, as vitamin P. Function 1. With the function of increasing capillary toughness, lowering cholesterol; 2. With the function of treating cardiovascular disease; 3. With the function of anti-virus and anti-inflammatory; 4. With the function of treating diseases such as hypertension and heart attack. Application 1. Pharmaceutical as capsules or pills; 2. Functional food as capsules or pills; 3. Health products as capsules or pills.